A Generalization of the Transmission/Disequilibrium Test in the Analysis of SNPs Data

摘要：

SNPs (Single Nucleotide Polymorphisms) refer to the single nucleotide differences at a certain location of genomic DNA, which become a new generation genetic marker after RFLP and SSRs due to its high accuracy and high stability. The linkage relationship between the disease locus and the SNP marker locus can be easily clarified by the transmission/disequilibrium test (TDT), however, the traditional TDT always assumed in these analyses that the genetic data are without errors, that is, there is not any miscoding of a persons correct marker genotype. Sources of error include nonpaternity, sample swaps in the lab, or genotyping errors. Obviously, there is an increase in the estimated recombination fraction between markers or between marker and disease, an increase in typeⅠerror rate, a decrease in power, and an incorrect estimation of background LD. The article proposed a general transmission/disequilibrium test allowe for random genotype errors, and then comparison of the two statistic methods was carried out.

关键词： SNP transmission/Disequilibrium Test genotyping errors TDT

作者: Chaowu Yang Xiaosong Jiang Hua-rui Du Xiaocheng Li Qing Zhu Qiong Wang

作者单位: College of Animal Science, Sichuan Agriculture University, Yaan, Sichuan, 625014, China Sichuan Province Institute of Animal Husbandry Research,Chengdu,610066,China College of life science and biotechnology,Sichuan Normal University,Chengdu 610068,China

会议类型: 国际会议

会议名称: The 1st International ELID-Grinding Conference(第一届镜面磨削技术国际会议)

会议地点: 长沙

会议语种:英文

页码: 704-709

在线出版日期: 2008-06-12（万方平台首次上网日期，不代表论文的发表时间）