Stability Model Construction of Long-Circulating Immuneliposome Targeting to Dendritic Cell Surface Molecule DEC-205 and Analysis of its Biological Characteristics

摘要：

Kinetic stability and coalescence stability theory of multi-dispersal systems have been advanced to construct the stability model of long-circulating immuneliposome targeting to dendritic cell surface molecules DEC-205 (anti-DEC-205 iLPSM). Then its physicochemical properties as well as biological characteristics is tested. The optimized liposomes show stable physicochemical properties when stores at 4 ℃ for 7 days. Under this condition, liposome size and size distribution do not noticeably change. Cumulative leakage rate of FITC-dextran from liposomes is less than 7%. Anti-DEC-205-immunoliposomes (anti-DEC-205 iLPSM), as drug carriers, can specifically recognize dendritic cells and deliver FITC-dextran into the cytoplasm. The construction of an anti-DEC-205 iLPSM model lays solid foundations for further work researching immune response after antigen targeting to DEC-205 receptors in vivo. Anti-DEC-205 iLPSM could become a new type of DC vaccine.

关键词： immunoliposome dendritic cells DEC-205 stability model

作者: Xue Hu Zhaofang Zeng Lili Chen

作者单位: Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education Biomedical Engineering Research Center,Chongqing Medical University,Chongqing 400016,China

会议类型: 国际会议

会议名称: The 1st International ELID-Grinding Conference(第一届镜面磨削技术国际会议)

会议地点: 长沙

会议语种:英文

页码: 664-668

在线出版日期: 2008-06-12（万方平台首次上网日期，不代表论文的发表时间）