Pharmacokinetic Study of Ginsenoside Re in Healthy Adult Volunteers
Aim To investigate the pharmacokinetics of ginsenoside Re (G-Re) in Chinese healthy subjects.Methods An open-label,randomized and crossover clinical trials recruited 16 healthy volunteers were carded oat for single-dose (100 and 200mg) and multiple-doses (100mg×2/d×7d)administration study.The concentrations of G-Re and its metabolites in human plasma and urine were determined using HPLC-MS/MS method.Results Pharmacokinetic parameters were determined from plasma G-Re oncentrations.After single-dose administration,there was no statistical difference of Tmax between 100 and 200mg doses,and the accumulative excretion rate of G-Re from urine after 24h administration were (0.0036±0.0021)% and (0.0017±0.0011)% for 100 and 200mg doses,respectively.After multiple-doses administration,the values of Cmax and AUC0-t of d7 were the double to those of d1,and no statistically significant difference was seen in Tmax and InCmax but was seen in InAUC0-t.The accumulative excretion rate of G-Re from urine after d7 administration were (0.0046±0.0025)%.Conclusion The present studies indicated that G-Re after orally in single-dose or multiple-doses administration is minimally absorbed and excretion from urine in human.There are not significant differences of the pharmacokinetic parameters between single-dose and multiple-doses study except for AUC0-t.
ginsenoside Re high performance liquid chromatography-tandem mass spectrometry pharmacokinetics
Wenjie Zhao Pingya Li Lei Lin Xin Hu
School of Pharmaceutical Sciences,Jilin University Beijing Hospital
国际会议
2008 International Conference on Ginseng(2008国际人参会议)
长春
英文
304-313
2008-09-01（万方平台首次上网日期，不代表论文的发表时间）