Antidepressant-like effects of Panax notoginseng saponins
Panax notoginseng saponin (PNS) is a major constituent of Panax notoginseng,the traditional Chinese medical formula,which has both stimulatory and inhibitory effects on the central nervous system.The monoamine hypothesis supposed that depression was a result of the depletion of 5-HT,NE and DA in addition to activation of monoamine oxidase in the CNS.There is no information available about the antidepressant activity of PNS.In the present study,we analyzed the effects of PNS on depressive-like behaviors in mice,using two animal models of depression.Our results showed that PNS treatment at 10 mg/kg significantly reduced the duration of immobility in both tail suspension and forced swimming tests.These doses that affected the immobile response did not affect locomotor activity.In addition,we also evaluated the neurochemical after chronic unpredictable mild stress test,results showed PNS produced a marked increase of 5-HT and NE levels at 10 mg/kg in both the frontal cortex and hippocampus.Dopamine levels were increased in the hippocampus and the striatum,moreover,5-HIAA levels were found increased in the hippocampus.These findings suggest that the antidepressant-like effects of PNS may relate to the increase in 5-HT and NE in the CNS,and the influence in the synthesis or metabolism of dopamine.
Panax notoginseng saponins Forced swimming Tail suspension Locomotor activity Antidepressant-like effect Monoamine
Yao Yang PAN Guo-Qing FENG JIA PEN GUIXING
Institute of Crop Science,Chinese Academy of Agricultural Sciences No.80 South Xueyuan Road,Haidian Institute of Special Economic Animal and Plant Science,Chinese Academy of Agricultural Sciences,No.1
国际会议
2008 International Conference on Ginseng(2008国际人参会议)
长春
英文
145-154
2008-09-01（万方平台首次上网日期，不代表论文的发表时间）