Panax ginseng,a potent modulator of mercuric chloride induced toxicity in albino rat,Rattus norvegicus (Berkenhout)
Animal and human life is dependent on plants directly or indirectly.Plants have made their access in medicine.Chinese medicine has established itself worldwide by its plant wealth.Panax ginseng is a perennial herb of the Araliaceae family native to the deciduous forests of the Eastern United State,China and Eastern Asia.Traditionally Panax ginseng root use has been divided into two categories:short term,to improve stamina,concentration,healing process,stress process,vigilance and work efficiency in healthy individuals and long term to,improve well being in delilaited and degenerative conditions especially those associated with old age1.Anti-tumor promoting activity of Panax ginseng is also reported2 but information is still lacking with regard to the precise action of Panax ginseng on some important metabolic activities of the liver in animal model.On the other hand,Mercuric chloride is a serious pollutant and also increased generation of oxidative free radicals with toxic effects in living organism.Primary exposure occurs through environmental contamination as a result of mining,smelting,extensive industrial and agriculture usage including inhalation and ingestion via the food chain.Mercuric chloride enters an organism and exhibit its toxicologic characteristic including neurotoxicity, nephrotoxicity3 and gastrointestinal toxicity with ulceration and haemorrhage4.This oxidative status of an individual is balanced by the activity of non-enzymatic antioxidant (tocopherol,ascorbic acid and beta carotene)and oxidant tissue enzymes (super oxide dismutase,catalase and glutathione peroxidase) which together prevent reactive oxygen species formation but tissue oxidant enzymes mitigate the damage caused by cells at a slow pace.However,non-enzymatic oxidant compounds produced secondary toxicity like lipid pcroxidation,liver injury,neurological disorder and head & neck cancer.Considering all these facts present study has been designed to find out modulating effect of Panax ginseng against mercuric chloride induced toxicity in albino rat (Berkenhout).
Prabhu N.Saxena
Toxicology Laboratory,Department of Zoology,School of Life Sciences,Khandari Campus,Dr.B.R.Ambedkar University,Agra-282002 (U.P.),India
国际会议
2008 International Conference on Ginseng(2008国际人参会议)
长春
英文
132-143
2008-09-01（万方平台首次上网日期，不代表论文的发表时间）