Analysis of network dynamics including hidden variables by symbolic-numeric approach

摘要：

We propose a symbolic-numeric method for estimating the kinetic constants in a biological network including hidden variables which mean that the behaviors of corresponding molecules cannot be directly measured. In the present method, an algebraic manipulation of the differential equations over the Laplace domain, formulated based on the assumption of linear relationships between the variables, is combined with the numerical fitting of the sampling data. The performance of the method is illustared for a part of MAPK network with the data measured by the transfection cell array in combination of the gene interference by siRNAs.

关键词： Symbolic Computation Numerical Optimization Network Dynamics Hidden Variable Bi-fan structure

作者: Daisuke Tominaga Yasuhito Tokumoto Masahiko Nakatsui Fuyan Sun Jun Miyake Katsuhisa Horimoto

作者单位: Computational Biology Research Center, AIST, 2-42 Aomi, Koto, Tokyo 135-0064, Japan The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033, Japan The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033, Japan Research Institute for Cell Engi

会议类型: 国际会议

会议名称: The Second International Symposium(OSB08)(第二届国际优化及系统生物学学术会议)

会议地点: 云南丽江

会议语种:英文

页码: 242-248

在线出版日期: 2008-10-31（万方平台首次上网日期，不代表论文的发表时间）