Mass flow model and essentiality of enzymes in metabolic networks

摘要：

Understanding the metabolism mechanisms in living organisms is a major task for postgenomic biology. Cellular metabolism is usually represented by a complex network of reactants connected by chemical reactions catalyzed by enzymes. In this paper, a mass flow conservation model is proposed to describe the process of cellular metabolism, which can be formulated as a linear programming model. Based on such model, the importance of an enzyme is quantitativelydefined in metabolic network according to the variation of mass flow and final products resulting from the deletion of the enzyme. This quantitative criterion can be used not only to predict the essentiality of enzyme but also to identify drug targets.

关键词： enzyme essentiality mass flow metabolic network linear programming

作者: Zhenping Li Rui-Sheng Wang Xiang-Sun Zhang

作者单位: School of Information, Beijing Wuzi University, Beijing 101149,China School of Information, Renmin University of China, Beijing 100872, China. Academy of Mathematics and Systems Science, CAS, Beijing 100190, China

会议类型: 国际会议

会议名称: The Second International Symposium(OSB08)(第二届国际优化及系统生物学学术会议)

会议地点: 云南丽江

会议语种:英文

页码: 182-190

在线出版日期: 2008-10-31（万方平台首次上网日期，不代表论文的发表时间）