Dynamics of the Mixed Feedback Loop Integrated with MicroRNA
The so-called mixed feedback loop (MFL) with microRNA is a small two-gene network where microRNA regulates the translation of mRNA by base pairing with the mRNA. It has been developed to show that the MFL is a representative motif of genetic regulation networks. The present paper is mainly concerned with the issues of dynamics for the mixed feedback loop (MFL)integrated with microRNA. A simple mathematical model of the motif is proposed based on the biochemical interactions. It is shown that, by itself, this motif can serve both as a monostable and a bistable switch depending on a kinetic parameter range. The results emphasize the role of microRNA in the function of genetic modules and the regulation of itself.
mixed feedback loop (MFL) microRNA dynamical Regimes
Ge Wang Jin Zhou
Shanghai Institute of Applied Mathematics and Mechanics Shanghai University, Shanghai, 200072, P.R.C Shanghai Institute of Applied Mathematics and Mechanics Shanghai University, Shanghai, 200072,P.R.Ch
国际会议
The Second International Symposium(OSB08)(第二届国际优化及系统生物学学术会议)
云南丽江
英文
174-181
2008-10-31（万方平台首次上网日期，不代表论文的发表时间）