Rho-GDIγ inhibits the proliferation of human glioma cells
Rho-GDIγ, one of GDP-dissociation inhibitors (GDIs) in the GTPases Rho-subfamily,plays a key role in modulating the activation of GTPases, and contributes to reorganization of the actin cytoskeleton, cell aggregation, cell-to-cell adhesion, membrane ruffling, cell motility, and so on. This study primarily shows that Rho-GDIγ, inhibits the proliferation of human glioma cells (HGC) U251. The result indicates that overexpression of Rho-GDIγ in U251 significantly inhibits cell proliferation and migration. Bioinformatics analyses indicate that Rho-GDIγ in mouse and human have the similar motifs, domains and structures. The results suggest that Rho-GDIγ, in human may be a regulation target in controlling the proliferation of human glioma cells.
Rho-GDIγ Glioma cells
Jiao Wang Xiao Li Xing-Ming Zhao Tieqiao Wen
Institute of Systems Biology, Shanghai University, 99 Shangda Road, Shanghai 200444, China Laborator Institute of Systems Biology, Shanghai University, 99 Shangda Road, Shanghai 200444, China
国际会议
The Second International Symposium(OSB08)(第二届国际优化及系统生物学学术会议)
云南丽江
英文
130-135
2008-10-31（万方平台首次上网日期，不代表论文的发表时间）