MicroRNA-mediated incoherent feedforward motifs are robust

摘要：

In this paper, we integrate transcriptional and posttranscriptional regulation into microRNA mediated incoherent feedforward motifs and analyze their dynamical behaviors and functions. The analysis show that the behaviors of the system are almost uninfluenced by the varying input in certain ranges and the introducing of delay and noise. The results indicate that microRNA-mediated incoherent feedforward motifs greatly enhance the robustness of gene regulation.

关键词： MicroRNA incoherent motif robust

作者: Feng-dan Xu Zeng-rong Liu Jian-wei Shen

作者单位: Institute of systems biology, Shanghai University, Shanghai 200444, china Mathematics department, Shanghai University, Shanghai 200444, China

会议类型: 国际会议

会议名称: The Second International Symposium(OSB08)(第二届国际优化及系统生物学学术会议)

会议地点: 云南丽江

会议语种:英文

页码: 62-67

在线出版日期: 2008-10-31（万方平台首次上网日期，不代表论文的发表时间）