Combined Analysis of Resting-State fMRI and DTI Data Reveals Abnormal Development of Function-Structure in Early-Onset Schizophrenia

摘要：

A combined analysis by integrating the resting-state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) is presented in this paper to investigate the structure-function relationship in early-onset schizophrenia.After fractional anisotropy in white matter was assessed,functional connectivity was analyzed with regions of reference which was defined according to the regions showed lower fractional anisotropy values.We found significant decreased functional connectivity in early-onset schizophrenia correlated with the regions of anisotropy changes.Our results demonstrated that the white matter lesions may disrupt the anatomical connectivity and inflect the functional connectivity between the frontal regions and other brain regions.

关键词： Functional connectivity Anatomical connectivity Resting fMRI Fractional anisotropy Early-onset schizophrenia

作者: Ming Ke Xing Huang Hui Shen Zongtan Zhou Xiaogang Chen Dewen Hu

作者单位: Lanzhou University of Technology,Lanzhou 730050,P.R.China College of Mechatronics and Automation,Nat College of Mechatronics and Automation,National University of Defense Technology,Changsha 410073,P.R The Second Xiangya Hospital of Center South University,Changsha 410073,P.R.China College of Mechatronics and Automation,National University of Defense Technology,Changsha 410073,P.R

会议类型: 国际会议

会议名称: The Third International Conference on Rough Sets and Knowledge Tevhnology(RSKT 2008)(第三届粗糙集与知识技术国际会议)

会议地点: 成都

会议语种:英文

页码: 628-635

在线出版日期: 2008-05-17（万方平台首次上网日期，不代表论文的发表时间）