Exploring L-tryptophan Synthesis Metabolism Network Through Extreme Pathway Analysis

摘要：

Metabolic pathway analysis is becoming more and more important for identification and quantification of all metaholites in (reconstructed) biochemical reaction networks.One of the most promising concepts for pathway analysis is extreme pathway analysis.Extreme pathways are a mathematically defined set of generating vectors that describe the conical steady-state solution space for flux distributions through an entire metabolic network.The objective of this study is to obtain a more detailed insight into L-tryptophan metabolism through network-based metabolic pathway analysis.Herein,the extreme pathways analysis is used for our study.Besides of historical biochemical pathways,the results also suggest that there are some novel pathways.And further experiments are needed to make a decision.

关键词： Metabolic pathways Extreme pathways Elementary modes L-tryptophan metabolism

作者: Dong Wang Li Liu Wenbo Xu Zhijun Zhao Jing Wu

作者单位: School of Information Technology,Jiang Nan University,Wuxi,214122,China State Key Laboratory of Food Science and Technology,Jiang Nan University,Wuxi,214122,China

会议类型: 国际会议

会议名称: 2008年国际电子商务、工程及科学领域的分布式计算和应用学术研讨会(2008 International Symposium on Distributed Computing and Applications for Business Engineering and Science)

会议地点: 大连

会议语种:英文

页码: 1332-1337

在线出版日期: 2008-07-27（万方平台首次上网日期，不代表论文的发表时间）