Detecting Molecular Adaptation of Interferon Gene by Codon-Substitution Simulation Models
Branch-Site and Site-specific Models are statistical simulation methods for detecting molecular adaptation at individual along specific lineages. The models not only indicate whether genes of phylogeny under positive selection or not, but also identify these codon sites under the positive selection, which promote gene divergence and polymorphism. For protein coding genes, detecting the positive selection sites is important to understand the structure and function of proteins. Interferon is a very important cytokine in innate immune system. Interferon genes present evolutional polymorphism because the innate immune factors are under high selective pressure. Using the computer models to simulate and analyze the molecular adaptation of interferon genes, it is found that interferon genes are under the positive selection, and the positive selection sites existing in the interferon gene sequences also are located. These results show that Branch-Site Models and Site-specific Models could detect molecular adaptation of innate immune genes in which are highly divergent.
Tanghuai Fan Min Tao Chengyu Hu Aiye Shi Lizhong Xu
College of Computer and Information Engineering Hohai University, Nanjing, China, 210098. College of Life Science, Nanchang University, Nanchang, China, 330047. College of Computer and Information Engineering, Hohai University, Nanjing, China, 210098.
国际会议
南宁
英文
2007-07-20（万方平台首次上网日期，不代表论文的发表时间）