Manipulating the Generation of Uniform O/W and W/O Emulsions Using Microfluidic T-junction
The purpose of this study is to generate monodisperse oil-in-water (O/W) and water-in-oil (W/O) emulsions using microfluidic T-junction. The materials of poly methyl methacrylate (PMMA) (hydrophobic) and glass (hydrophilic) were employed for microfluidic chip fabrication. Our strategy is based on the shear focus effect and sheath effect (focusing) to form uniform self-assembling sphere structures, the so-called O/W and W/O emulsions, in the T-junction microchannel. Results show that the size from 31μm to 43μm in diameter of O/W emulsions was generated by using the glass-based microfluidic chip. In addition, results show that the size from 70μm to 220μm of W/O emulsions was available by utilizing the PMMA- based microfluidic chip. These W/O emulsions were further applied to Ca-alginate microparticles (Ca-alg MPs) synthesis. The proposed microfluidic chips are capable of generating relatively uniform micro-droplets and have the advantages of actively controlling the droplet diameter, and having a simple and low cost process, with a high throughput.
T-junction Emulsions Microfluidic
Keng-Shiang Huang Sheng-Ji Lee Meng Sun Qun Fang Yu-Cheng Lin
Department of Engineering Science, Cheng Kung University Insititute of Microanalytical Systems, Zhejiang University
国际会议
The First Shenyang International Colloquium on Micrifluidics(首届沈阳国际微流控学术论坛)
沈阳
英文
78-81
2007-10-21（万方平台首次上网日期，不代表论文的发表时间）