会议专题

Transferable Properties of Phenotypic and Behavioral Defects from Manganese Exposure in Caenorhabditis elegans

Whether the multi-biological toxicity from manganese (Mn) exposure could be transferred from exposed animals to progeny has not been clarified. In this study, we explored the model organism, Caenorhabditis elegans, to analyze the multiple toxicities of Mn and their transferable properties. Three concentrations of Mn (2.5, 75, and 200 μM) were tested and the changes of various endpoints compared with wild-type animals were investigated in each group. Our results indicate that the Mn toxicity caused multi-biological defects with a concentration-dependent manner by affecting the life span, development, reproduction and locomotion behaviors in nematodes. Moreover, these multi-biological defects could be transferred from exposed animals to their progeny, and most of the defects in progeny could only be partially recovered compared to their parents. The defects caused by Mn exposure were further summarized into three groups according to their transferable properties. Therefore, our results suggest that most of the Mn exposure-caused multi-biological defects could be transferred from exposed animals to their progeny in C. elegans.

manganese toxicosis transferable property C. elegans

HU Yaou YE Boping WANG Dayong

Department of Genetics and Developmental Biology, Southeast University, Nanjing 210009, Jiangsu, Chi School of Life Science & Technology, China Pharmaceutical University, Nanjing 210009, Jiangsu, China Department of Genetics and Developmental Biology, Southeast University, Nanjing 210009, Jiangsu, Chi

国际会议

2007环境科学与技术国际会议(The 2007 International Symposium on Environmental Science and Technology)

北京

英文

2007-11-13(万方平台首次上网日期,不代表论文的发表时间)