Stereoselective Studies on Different Pharmacokinetic Behavior and Tissue Distribution of Theta-cypermethrin Enantiomers in Rabbit
Theta-cypermethrin (TCYM) is a potent pyretroid insecticide. Enantioselective kinetics, tissue distribution and chiral inversion of TCYM in rabbits were investigated via intravenous injection. The concentrations of TCYM enantiomers in samples were determined by a HPLC with Diode Array Detection (DAD) and a cellulose-tris-(3, 5-dimethylphenylcarbamate)- based chiral stationary phase (CDMPC). After intravenous administration of racemic TCYM, the (-)- (R)-(1S)-trans-TCYM was prevailing in plasma. The(-)- (R)-(1S)-trans-enantiomer of the area under the concentrationtime curve (AUC<,0-∞>)was 248.94μg/(mL· min). The total plasma clearance value (CL) of (-)-(R)-(1S)-trans- TCYM was 30.00mL/(min·kg). The (-)-(R)-(1S)-trans-TCYM was enantioenriched in tested tissues except in lung. These results indicated substantial stereoselectivity on kinetics and tissues distribution of TCYM enantiomers in rabbits.
Stereoselective Theta-cypermethrin Pharmacokinetic Behavior Tissue Distribu-tion Rabbit
Wang Qiuxia Qiu Jing Zhou Zhiqiang Cao Aaocheng Zhu Wentao
Plant Protection Institute of Chinese Academy of Agriculture, Beijing 100094, P. R. China Institute of Quality Standards and Testing Technology for Agro-products, Chinese Academy of Agricult Department of Applied Chemistry, China Agricultural University, Beijing 100094, P. R. China
国际会议
北京
英文
237-247
2007-10-09（万方平台首次上网日期，不代表论文的发表时间）