Efficient Catalytic Asymmetric Synthesis of α-Substituted Phenyloxyacetyloxy and Aroyloxy Phosphonates

摘要：

Optically active α-substituted phenoxyacetyloxy and aroyloxy phosphonates have been synthesized via catalytic asymmetric hydrogenation of the corresponding prochiral α, β- unsaturated phosphonates using Rh (I)/(R, R)-Me-DuPhos as the catalyst in methanol at 18℃. The asymmetric hydrogenation reaction exhibits excellent enantioselectivity with enantiomeric excesses from 91％ to 96％.

作者: Liu Hui Xiao Wenjing

作者单位: The Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, P. R. China

会议类型: 国际会议

会议名称: 第三届“农药与环境安全国际学术研讨会暨第七届“植物化学保护和全球法律一体化国际研讨会(3rd International Symposium on Pesticide and Environmental Safety & 7th International Workshop on Crop Protection Chemistry and Regulatory Harmonization)

会议地点: 北京

会议语种:英文

页码: 384-394

在线出版日期: 2007-10-09（万方平台首次上网日期，不代表论文的发表时间）