Genotoxicity evaluation of arsenic in Oreochromis niloticus

摘要：

The genotoxic potential of trace metals is a major issue in the fish health risk from exposure, hence, the aim of this investigation is to evaluate the genotoxic effects of arsenic in tilapia (Oreochromis niloticus). In this experimental work, acute toxicity of arsenic was determined and recorded asLC50= 68. 4 mg/l in the 96hr toxicity test. Tilapia were exposed to chronic toxicity (1/10 LC50) for 30 days, concentration of arsenic in various tilapia tissues revealed significant correlation with a higher value in liven Altrations in liver enzymes revealed elevated values of ALK. phosphatase and LDH. The comet assay (in vitro) technique was carried out to quantify basal DNA damage and monitoring the genotoxic effects of arsenic. The frequancy of comet cells was significantly correlated with arsenic concentration and duration of exposure. This work could confirm the genotoxicity of arsenic as a water pollutant.

关键词： Arsenic Genotoxicity Risk assesment Tilapia

作者: I. M. K. Abumourad S. F. Elabd

作者单位: Hydrobiology department, Veterinary division, National research centre, Egypt Molecular biology department, genetic engineering and biotechnology research centre, Menooufia unive

会议类型: 国际会议

会议名称: 第九届痕量元素生物地球化学国际会议(9th International Conference on the Biogeochemistry of Trace Elements)

会议地点: 北京

会议语种:英文

页码: 758-759

在线出版日期: 2007-07-15（万方平台首次上网日期，不代表论文的发表时间）