Effect of chronic arsenic exposure on kidney function of people with diabetes and validation of its effect in a rat model
Adverse health effects including cancers caused by chronic arsenic exposure are of global significance. Diabetes is another chronic health disease that is on the increase worldwide. There have been several epidemiological studies implicating the positive association between arsenic exposure and diabetes mellitus. We studied villagers with and without diabetes from arsenic-endemic areas and a nearby control site in Xinjiang Province PR China. Water and urinary arsenic were assayed for exposure measurement. Urinary NAG (a kidney function test), blood glucose, triglyceride, cholesterol, high density lipid and low density lipid were measured. Villagers from endemic areas had higher urinary arsenic concentrations. The NAG results also suggest that chronic arsenic exposure contributes a significant adverse impact on the kidney function of villagers in the endemic areas. This observation was validated in rats which were chronically exposed to arsenic in drinking water. However, blood glucose levels of diabetic individuals were lower than those from the control site. The relationship of chronic arsenic exposure and diabetes mellitus requires further investigation. A rodent model may be a useful tool for study of this type.
arsenic diabetes kidney function humans rats
Jack C. Ng Jian Ping Wang Sheng Ling Wang
National Research Center for Environmental Toxicology (EnTox), The University of Queensland, 39 Kess National Research Center for Environmental Toxicology (EnTox), The University of Queensland, 39 Kess Centre for Disease Control of Xinjiang, PR China
国际会议
第九届痕量元素生物地球化学国际会议(9th International Conference on the Biogeochemistry of Trace Elements)
北京
英文
861-862
2007-07-15（万方平台首次上网日期，不代表论文的发表时间）