Dynamic Prediction of Cellular Responding Ion Radiation (IR) based on an Improved Modeling of P53 Stress Response Networks

摘要：

Under acute genome stresses, P53, a vital anticancer gene, trigger the cell cycle arrest and cell apoptosis by regulating the downstream genes and the complicated signal pathways. To simulate the cellular responding DNA damage under different IR dose domains, an improved model of P53 stress response networks is proposed at single cell level. The model can be used to investigate the dynamic and kinetic processes of P53 stress response networks under different IR dose. Also, it can present the plausible outcomes of cellular response in fighting against DNA damage.

作者: Jineng Qi Shihuang Shao Jinli Xie Guangzhu Yu

作者单位: College of Information Sciences and Technology Donghua University, Shanghai 201620, P. R. China

会议类型: 国际会议

会议名称: 2007年IEEE灰色系统与智能服务国际会议(2007 IEEE International Conference on Grey Systems and Intelligent Services)

会议地点: 南京

会议语种:英文

在线出版日期: 2007-11-18（万方平台首次上网日期，不代表论文的发表时间）