Characteristic Comparative Studies of Huperzine A-PLGA Microspheres Prepared by Two Different Emulsion Methods

摘要：

Huperzine A (HupA) microspheres were prepared by using O/W and O/O emulsion-solvent evaporation methods. The physicochemical characteristics of HupA-PLGA microspheres were compared on the partical size and the distribution, the surface property, the encapsulation efficiency and the drug release rate in vivo/in vitro. Te results showed that the method prepared by using O/O emulsion-solvent evaporation technic are more suitable to be developed as a long-acting microsphere injection.

关键词： Huperzine A Microsphere Burst effect Encapsulation efficiency O/W and O/O emulsion-evaporation

作者: Pan Feng Chen Qinghua Zhu Dayuan

作者单位: Division of pharmaceutics, Shanghai Institute of Pharmaceutical Industry, NO. 1111 Zhongshan NO. 1 R Shanghai Institute of Materia Medica, Chniese Academy of Science, Shanghai, 201203, China

会议类型: 国际会议

会议名称: 第三届国际药物制剂论坛

会议地点: 上海

会议语种:英文

页码: 121-129

在线出版日期: 2007-10-19（万方平台首次上网日期，不代表论文的发表时间）