Study on different preparation methods of pirarubicin liposomes

摘要：

To explore the promising industrialized technique for the preparations of pirarubicin liposomes, pirarubicin was encapsulated into the liposomes using three different preparing techniques, modified transmembrane ammonium sulfate gradient, thin film evaporation and micro-fluidic technique. Therefore the preliminary study of the morphology, particle size distribution, entrapment efficiency and drug loading amount of liposomes were investigated. TEM showed the THP liposomes were small spherical and sphere-like vesicles. Particle size determination showed that the average particle size were about 400(nm), and the micro-fluidic technique of liposomes had mono-disperse size distribution. And the entrapment efficiency of the three techniques were 96.0.％, 79.3％ and 86.4％ respectively, accordingly the drug loading amount were 4.8％, 4.0％ and 4.3％.

关键词： Pirarubicin liposomes modified transmembrane ammonium sulfate gradient micrefuidic technique thin film evaporation anti-tumor

作者: Wenjuan Cong Qingfei Liu Qiang Su Guoan Luo Yiming Wang

作者单位: Pharmacy School, East China University of Science and Technology, Shanghai, 200237;Institute of Biom Institute of Biomedicine, Tsinghua University, Beijing 100084 Shenyang Pharmaceutical University, Shenyang 110016

会议类型: 国际会议

会议名称: 第三届国际药物制剂论坛

会议地点: 上海

会议语种:英文

页码: 162-169

在线出版日期: 2007-10-19（万方平台首次上网日期，不代表论文的发表时间）