Association between polymorphisms of Toll-like receptor 7/8 and asthma in a southern Chinese Han Population
Background: Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns (PAMPs) of microbes in the environment and link human innate and adaptive immunity. Although TLRs are involved in the pathogenesis of asthma and atopy, there is no report about the association between TLR7 or TLR8 single nucleotide polymorphisms (SNPs) and asthma. Objectives: To evaluate the effects of TLR7/8 polymorphisms on asthma risk and asthma-related phenotypes in a southern Chinese Han Population. Methods: Genotyping of each SNP was performed using multiplex PCR in conjunction with tagged array single base extension technology. We conducted case-control and case-only association studies between the selected SNPs in TLR7/8 and asthma-related phenotypes. Results: The T allele of rs5935436 SNP in TLR7 was protective from developing asthma in males adjusted odds ratio (ORs)=0.126,95％ confidence interval (CIs)= 0.016-0.995. The homozygote AA of rs3761623 and GG of rs3764880 were positively associated with lower forced expiratory volume in one second percentage of the predicted value (％FEV<,1>) and asthma severity in female asthmatics. These results were confirmed by haplotype analysis. Conclusion: TLR7/8 polymorphisms may play a considerable role in the pathogenesis of asthma in a gender-dependent manner. It could be clinically useful both for identifying patients at risk of asthma and for preventing its occurrence.
Asthma Atopy Eosinophils Haplotype IgE Phenotype Polymorphism Sex difference Toll like receptors X chromosome Susceptibility
Qian Zhang Kai-Sheng Yin Fen-Hong Qian Lin-Fu Zhou Qiang Du Ying Wang Zhi-Bin Hu Guang-Fu Jin Jian-Ling Bai
Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanji Department of Genetics, Chinese National Human Genome Center at Shanghai, Shanghai 201203, China Department of Epidemiology and Biostatistics, Cancer Research Center, Nanjing Medical University, Na Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, N
国际会议
上海
英文
289-297
2007-11-03（万方平台首次上网日期，不代表论文的发表时间）