Preparation and Biocompatibility Study of Nano-hydroxyapatite Composite Materials
In order to prepare scaffold materials for tissue engineering formed by nano-hydroxyapatite, Chitosan and growth factors (nHA/CS/bFGF)and to detect characterization and biocompatibility, we firstly adopt chemical precipitation to obtain nano-hydroxyapatite which is then mixed with chitosan in various mass ratios and handled by mechanical milling. Secondly, we add both pore-making agent and dichlorobenzene with the same masses into the above material, treat it by ball-milling and pour citric acid solution in to obtain the test sample after the procedure of blending, pressure and ejection. Disinfect it and dip into basic fibroblast growth factor,(bFGF ) solution for freeze drying.Finally, we use both rotating target XRD and SEM to represent the sample composition and fractal characteristics and detect biocompatibility in accordance with ISO 16993-2002. The experimental results indicate that the sample material meets the design requirements with pores different in size and reaches the biological indicators, which shows it is suitable for tissue engineering material.
Nano biomaterial Hydroxyapatite Chitosan Biocompatibility Tissue Engineering basic fibroblast growth factor(bFGF)
王兰磊 杨加峰 孙康宁 刘爱红 邱丽萍 李爱民
四川大学华西口腔医学院 口腔正畸科 610041 山东大学第二医院 整形外科 250061;山东省济南市山东大学材料液态结构及其遗传性教育部重点实验室 山东大学第二医院 整形外科 250061 山东省济南市山东大学材料液态结构及其遗传性教育部重点实验室
国际会议
成都
英文
2007-11-19（万方平台首次上网日期，不代表论文的发表时间）