Preparation and characterization of uniform-sized magnetic chitosan nano-particles used as targeted-drug carriers
The control of size and size distribution of particles is necessary and critical in targeted-drug therapy. The magnetic chitosan (CS) nano-particles were prepared by a suspension cross-linking technique in this study. CS was dissolved in 1 wt.％ aqueous acetic acid containing 0.9 wt.％ sodium chloride and dispersed magnetic Fe3O4 nanoparticles, which was used as a queous phase. A mixture of liquid paraffin and petroleum ether 7:5 (v/v) containing Span-80 emulsifier was used as an oil phase. The water phase was added dropwise into the oil phase under rapid stirring to form W/O emulsion. Then Glutaraldehyde as cross-linker was slowly dropped into the W/O emulsion to crosslink the CS droplets. The preparation condition for obtaining uniform-sized and nano-sized CS magnetic particles was optimized. The product was characterized by X-ray powder diffractometer (XRD), transmission electron microscope (TEM), scanning electron microscope (SEM), dynamic laser scattering analyzer (DLS), FTIR spectrophotometer (FTIR), etc. The most important aspect for the magnetic carrier is a sufficient magnetic field intensity produced by least ferromagnets to excite all the dipole moments of each 0.05 g magnetic carrier 2 cm far away from the ferromagnets, so the magnetic response of the product in the magnetic field was also analysed and evaluated carefully. As a result, the prepared uniform-sized magnetic CS particles were in the range of nano-size with prominent magnetic response and spherical morphology, the average diameter achieved 45.5 nm with the range from 35-55 nm, the relative magnetic response was detected as 0.0472 g/(2 cm· 0.05 g magnetic CS nano-particles) and a 32.6 mT magnetic field which was produced by four ferromagnets was found to be sufficient to excite almost all of the dipole moments of 0.05 g composite magnetic nano-particles 2 cm far away from the ferromagnets,. In conclusion the magnetic CS nano-particles obtained were qualified for the carriers in the targeted delivery of drugs.
CS magnetic nano-particles uniform-sized suspension cross-linking magnetic response
赵原璧 邱祖民
南昌大学 环境科学与工程学院,江西 南昌,330031
国际会议
成都
英文
2007-11-19（万方平台首次上网日期，不代表论文的发表时间）