Study on Thermotherapy Effects of Carboplatin-Fe@C Magnetic Nanometer Medicine Targeting at Liver Cancer
The Fe@C nanocage-loaded chitosan microspheres (Fe@CN-CN) are prepared in this paper, and the rule of induction heat production in alternating magnetic field and effects of magnetic target thermotherapy on rat with transplanted liver cancer in vivo are also investigated. Fe@CN-CN are prepared by using the reverse micro-emulsion method. High-frequency alternating magnetic field is used to explore its rule of induction heat production in vitro. Meanwhile, the magnetic target heating conditions and thermotherapy effects of Fe@CN-CN on tumor tissue of 36 rats with transplanted liver cancer model(randomly divided into 3 groups, group A is saline group, group B is microsphere group, group C is microsphere thermotherapy group)are observed. The experimental results showed that the heating rate and constant temperature of Fe@CN-CN saline dispersion solution in alternating magnetic field increased with the increasing of Fe@CN-CN concentration and current intensity of magnetic field. Under the condition of 8 g/L Fe@CN-CN and current intensity at 27A, the dispersion solution can reach 42℃. In vivo, tumor tissue in alternating magnetic field can reach 42.6±0.20℃ within 10 mins and keep this temperature for 30 mins. Whereas the highest temperature of right hepatic lobes and rectum are 40.8±0.18℃ and 38.2±0.19℃, respectively. The size of tumor tissue in group C is only 42.6％ of that of group A. Tumor inhibition rate of C group could reach 48.5％, which is 1.5 times higher than that of group B. So Fe@CN-CN has good magnetic target force and induction heating performance, which can target the location of liver tumor tissue to effectively increase the temperature of tumor tissue by the action of alternating magnetic field and promote apoptosis of tumor cells for achieving significant therapeutic effects. It is a potential nanometer-grade magnetic target thermotherapy carrier.
carbon-coated iron nanoparticles nanocage-loaded magnetic particle carrier tumor-targeting thermotherapy liver cancer alternating magnetic field
李富荣 严文辉 郭跃华 齐晖 任莉莉 周汉新
暨南大学第二临床医学院(深圳市人民医院)临床医学研究中心 深圳 518020
国际会议
成都
英文
2007-11-19（万方平台首次上网日期，不代表论文的发表时间）