Synthesis of magnetic nanobiomaterials and its biological effects

摘要：

Iron oxide and its hydrate nanoparticles, for example, nanoFe304 and nanoFe304 with hydroxyl, were synthesized by hydrothermal method, theirsizes and features are evaluated by infrared spectra and Scanning Electron Microscope (SEM) et al. The dimensions of these nanoparticles are about 50-120 nm. In the investigation of influence of nanoFe304 and nanoFe304 with hydroxyl on crystalline states of amino acid molecules, their crystalline forms are different to that of pure amino acid. The positions and width of the nanoparticles peaks in the infrared spectrum are changed largely. From the microscope observation and infrared spectrum of re-crytalline amino acids we see that the nanoFe304 and nanoFe304 with hydroxyl can change the structure of amino acid molecules. To study the toxicity of synthesized nanoparticles, the MTT (3-(4,5-dimethyl-thiazol2-yl)-2,5 diphenyltetrazolium bromide) assay was used. The OD value (optical density) was used to calculate RGR％ (Relative Generation Rate) of cells, which determined the grade of cytotoxicity. The RGR of nanoparticles of iron oxide and its hydrate are about 1 to 2, which indicate that they have lower toxicity.

关键词： magnetic bio-nanomaterial infrared spectrum cell proliferation biological effect synthesis

作者: 庞小峰 邓波 赵强

作者单位: 电子科技大学生命科学与技术学院纳米材料研究室,四川,成都,610054

会议类型: 国际会议

会议名称: 第六届中国国际纳米科技研讨会

会议地点: 成都

会议语种:英文

在线出版日期: 2007-11-19（万方平台首次上网日期，不代表论文的发表时间）