Lamellar Liquid Crystals Formed by Pharmaceutically Accepted Brij97 Surfactant
Lamellar liquid crystals of Brij 97 aqueous solutions were investigated by means of SAXS and rheological techniques at 25 ℃, when adding varied additives including IPM, oleic acid, ionic liquid bmim-PF6 and bmim-BF4. All the lamellar phases show high elasticity indicated by their mechanical and discrete relaxation spectra, which can be expected to be an advantage as drug delivery vehicles. In addition, to compare with other systems, the lamellar phase formed in Brij 97/water/IPM system has the largest molecule interfacial area and the lowest storage and loss moduli, implying its weak network strength and less stable internal structure. Moreover, Brij 97/water/ bmim-PF6 system exhibits fluid-like viscoelastic property to some extent. These differences are analyzed through SAXS data as the different location of the additive in the lamellar phase, in which oleic acid is principally penetrated between the surfactant molecules to participate the formation of the interfacial layer, while bmim-BF4 and bmim-PF6 are mainly located in the hydrophilic domain and IPM is solubilized in the nonpolar area of the lamellar structures.
Brij 97 Lamellar liquid crystals SAXS Rheology
王仲妮 孟琳 刁兆玉 周武
山东师范大学化学化工与材料科学学院,济南250014
国际会议
成都
英文
2007-11-19（万方平台首次上网日期，不代表论文的发表时间）