Synthesis and characterization of novel amphiphilic multifunctional octadecyl quaternized carboxymethyl chitosan
The design for the construction of more-effective delivery vectors is very important. Typically, a new kind of multifunctional octadecyl quaternized carboxymethl chitosan(QACMC) with varying degree of substitution (DS) and molecular weight (Mw) were prepared using nucleophilic substitution reaction, the structure of the modified chitosan were characterized by FT-IR,1H-NMR, XRD and gel permeation chromatography. The results showed that QACMC has many unbeatable advantages. It exhibited excellent solubility both in water and organic solvents such as chloroform, DMF, THF and toluene when Mw was above 1×104, which greatly expands its application. QACMC has amino group, carboxymethyl salt group and octadecyl quaternized group simultaneously, so targeting materials, such as antibodies, can be connected to some of these chemical groups. It also has a high and perfect crystallinity compared with chitosan and other derivatives. TEM images indicated that it can be made into spherical micelles and double-membrane structure micelles. QACMC micelles also have the solubilization function of pyrene. Zeta potential of QACMC could reach +52.72mV when grafting percentage of quaternary group was about 105.0％, which means that gene and some proteins can be adsorbed on the surface of the nanoparticles through static effect. QACMC can be considered as a good potential vector for genes and drugs.
Quaternized carboxymethyl chitosan amphiphilic Micelle gene and drug vector
梁晓飞 王汉杰 罗浩 常津
天津大学材料学院纳米生物技术研究所 天津 300072
国际会议
成都
英文
2007-11-19（万方平台首次上网日期，不代表论文的发表时间）