TOPOLOGY OPTIMIZATION OF MEMS-BASED BIODEGRADABLE CONTROLLED DRUG DELIVERY SYSTEM FOR COMBINATION THERAPY
MEMS-based biodegradable controlled release system with micro multi-chambers can respectively enclose two drugs in different chambers to realize a combination therapy. In order to synchronously obtain the linear release of two drugs, it is necessary to completely investigate the topology optimization of the system. This paper introduces the theory of multi-objective topology optimization into MEMS-based biodegradable controlled release system for the combination therapy. Furthermore, a new method of CA-based evolutionary structural optimization (CA-ESO) is presented to accomplish the topology optimization of this controlled release system. The result shows that the optimized drug delivery system can achieve the objective of the synchronizing linear release for two drugs. The conclusion illustrates that the CA-ESO method proposed in this paper is validity for the topology optimization of MEMS-based biodegradable controlled release system.
MEMS topology optimization biodegradable controlled drug delivery system combination therapy
Ruixia Yu Hualing Chen Tianning Chen Hairong Wang
School of Mechanical Engineering, Xi’an Jiaotong University, Xi’an 710049, P.R. China
国际会议
海南三亚
英文
2007-01-10（万方平台首次上网日期，不代表论文的发表时间）