Study on the Property of the Electrospinning Silk Fibroin(SF)/gelatin Blend Nanofibers for Scaffolds
SF/gelatin blend nanofibers matrices as scaffolds were fabricated successfully via electrospinning with different weight ratio in formic acid, by the formation of intermolecular hydrogen bonds and the transformation of SF microstructure, which afforded scaffolds excellent mechanical properties. Comparing with the SF nanofibers scaffolds, the breaking tenacity of blend nanofiber scaffolds increased from 0.95N/mm<2> up to 1.60N/mm<2>, average fiber diameter was 89.2nm, specific elongation was 7.6％, the porosity was 87％, the pore diameter was 142nm. MTT, H&E stain and SEM results showed, by addition of gelatin, the adhesion, spreading and proliferation of human umbilic vein endothelium cells (ECV304) and mouse fibroblasts (L929) on the SF/gelatin nanofibers scaffolds were definitely better than the SF nanofiber scaffolds, which showed that the SF/gelatin blend nanofiber matrices met the requirements for the scaffolds and may be a good candidate for blood vessel engineering scaffolds.
Electrospinning Nanofibers Silk fibroin Gelatin Scaffolds
YIN Gui-bo ZHANG You-zhu BAO Wei-wei WU Jia-lin SHI De-bing DONG Zhi-hui
College of Material Engineering, Suzhou University, Suzhou 215021, P. R, China;Nantong Textile Vocat College of Material Engineering, Suzhou University, Suzhou 215021, P. R, China Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China
国际会议
苏州
英文
381-385
2007-09-13（万方平台首次上网日期，不代表论文的发表时间）