Selection of 3DP Parameters for Fabricating DDS
To optimize several three-dimensional printing (3DP) parameters for fabricating drug delivery systems (DDS) with standard-met mechanical properties. With acetaminophen as model drug, hydroxypropyl methylcellulose (HPMC) as matrix polymer, 5.0(w/v)％ polyvinylpyrrolidone (PVP) in 90:10 (v/v) ethanol: water as binder solution, DDS were fabricated directly from the computer aided design models using 3DP processes under different parameters such as diameters of drug particles, line-to-line spacing and printing passes of the binder solution. The hardness and friability of the DDS were determined by a hardness tester and a drum friabilator. An environmental scanning electron microscopy was taken to envisage the microstructure of the tablets. Results showed that the tested 3DP parameters had remarkable influence on the mechanical performance of DDS. The predominant binding mechanisms were different when different amount of binder solution was dispensed. Different binding mechanisms could be combined together to ensure the tablets have enough strength to withstand the subsequent handling procedures. Selecting suitable 3DP parameters was important for fabricating DDS with standard-met mechanical properties.
Three-dimensional printing parameters drug delivery systems hardness friability
YU Dengguang ZHU Limin WANG Yungan YANG Xiangliang
Institute of Biological Science and Technology, Donghua University, Shanghai 200051, China FoChif Mechatronics Technology Co. Ltd., Shanghai 200233, P. R. China College of Life Sci & Tec, Huazhong University of Sci & Tec, Wuhan 430074, China
国际会议
上海
英文
663-665
2007-10-15（万方平台首次上网日期，不代表论文的发表时间）