Effects of Molecular Weight and Degree of Acetylation on the Release of Nitric Oxide from Chitosan-NO Adducts
A series of nitric oxide modified chitosans with different molecular weight and degree of acetylations are synthesized, and the NONO group is formed by binding to the amidic group of chitosan. The effect of molecular weight and degree of acetylation on the NO release is investigated by the Griess assay. The results show a bell-shaped distribution in the range of degree of acetylation from 6-95％ with the maximum NO release at DA??50％. The maximum NO release is directly proportional to the molecular weight for chitosans with the same degree of acetylation. The X-ray diffraction (XRD) pattern indicate that these release properties of chitosan-NO adducts are influenced greatly by the crystalline form of chitosans. The maximum NO release of chitosan-NO adducts is in generally agreement with the intensity of reflections at low Bragg angles (2θ=8.6-11.1°), which denote a relaxed hydration crystalline form and NO molecules could penetrate this crystal and react with the chitosan molecules.
Chitosan Nitric oxide Diazeniumdiolates Nitric oxide release Crystal structures
GAO Qun WANG Guojian WAN Ajun
School of Materials Science and Egineering, Tongji University, Shanghai 200092, P. R. China School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai 200240, P. R. C
国际会议
上海
英文
812-814
2007-10-15（万方平台首次上网日期，不代表论文的发表时间）