Preparation of Fe<,3>O<,4>/Chitosan Composite Nanoparticles for Guided Delivery of Drugs in Photodynamic Therapy
The aim of this study is to prepare magnetic chitosan composite nanoparticles (MCCPs) loaded with a photosensitiser (PS) for photodynamic therapy (PDT) and then to investigate the singlet oxygen release behaviour of PS from the MCCPs. In this work, Fe<3>O <4> nanoparticles were synthesized by the chemical co-precipitation, and the PS was adsorbed on the surface of the magnetic Fe<,3>O<,4> nanoparticles. The MCCPs loaded with drug were prepared by the electrostatic self-assembly technique. The size of the obtained quasi-spherical MCCPs was 20.6±5.1nm from the Transmission electron micrographs (TEMs). The drug encapsulation efficiency was confirmed by FT-IR and measured by UV spectrometry. The ability to generate singlet oxygen of the MCCPs was performed at 630nm as the excitation wavelength and detected with UV spectrometry. The results showed that the drug encapsulation efficiency was~65.4％, drug loading was~4.9％ and the MCCPs could gradually generate singlet oxygen within 70min of exposure. The above facts suggested that the MCCPs could be applied in a promising drug release-controlling system for the guided photodynamic therapy.
chitosan magnetic nanoparticles photodynamic therapy singlet oxygen UV.
HUANG Peng ZHOU Xingping CHEN Zhilong NI Siyu WANG Xiaqin
Institute of Biological Sciences and Biotechnology, Donghua University, Shanghai 201620, P. R. China College of Material Science and Engineering, Donghua University, Shanghai 201620, P. R. China
国际会议
上海
英文
953-955
2007-10-15（万方平台首次上网日期，不代表论文的发表时间）