Lack of Upregulation for Sheep Beta-Defensin 1 mRNA in vivo upon Salmonella enterica Infection in Digestive Tract
Defensin is antimicrobial peptide that play an important role in the innate immune in digestive and respiratory tracts. Up to date, the function of sheep beta-defensin 1 (sBD1) is still unknown. We used a real-time RT-PCR method to detect the expression of sBD1 and sheep IL-8 during Salmonella enterica infection in digestive tract. Salmonella enterica infection were performed by part of jejunum injection and taken by mouth, the results showed Significant upregulations in expression of sheep IL-8. However, the decreased changes in expression of beta-defensin 1 were observed. We conclude that beta-defensin 1 was lack of upregulation during S. enterica infection under these conditions.
sheep beta-defensin 1 sheep IL-8 real-time RT-PCR Salmonella enterica innate immunity
SHENG Jinliang CHEN Chuangfu YANG Xia WANG Yuanzhi ZHANG Hui CAO Xudong HU Wenge REN Yan
College of Animal Science and Technology, University of Shihezi, Shihezi 832003, Xinjiang, China College of Medicine, University of Shihezi, Shihezi 832003, Xinjiang, China
国际会议
2007年中国科协科技年会(The Annual Conference of the China Association for Science and Technology)
武汉
英文
202-206
2007-09-08（万方平台首次上网日期，不代表论文的发表时间）