Changes of Vascular Wall and Total Cholesterol, High Density Lipoprotein, Oxidized low Density Lipoprotein, Nitric Monoxide and Lipide Peroxidation in Serum after Arcuate Nucleus Lesioned
After arcuate nucleus of hypothalamus lesioned with monosodium glutamate, changes of vascular wall and total cholesterol, high density lipoprotein, oxidized low density lipoprotein, nitric monoxide and lipid peroxidation in serum were investigated to explore the effect of hypothalamic arcuate nucleus on the development of atherosclerosis. In experimental group of arcuate nucleus lesioned, degeneration of endothelial cells and edematous nuclei of endothelium can be observed, vesicles of various sizes in subendothelial tissue and smooth muscle cells migrated from tunica media to tunica intima through ruptured elastic interna, and the levels of total cholesterol, oxidized low density lipoprotein and lipid peroxidation in serum was significant higher and nitric monoxide was lower than that of control subjects. After cutting infundibulum, degeneration of endothelial cells with edematous nucleus and proliferous collagenous fibers around ruptured myo- endothelial junction were also observed. The structure of control group remained intact. Results suggest that hypothalamic arcuate nucleus might be of significance regulative effect in the development of atherosclerosis.
Atherosclerosis Arcuate nucleus Infundibulum Total cholesterol Oxidized low density lipoprotein High density lipoprotein Nitric monoxide Lipid peroxidation
Xiaobong Jin Yirong Xu Bing Liu Yaan Yang Mincheng Wang Kaiyun Wu
Department of Anatomy, Medical college, Soochow University, Suzhou 215123, China
国际会议
首届国际断层影像解剖学研讨会(The 1st International Symposium on Sectional and Inaging Anatomy)
青岛
英文
185-188
2007-12-15（万方平台首次上网日期，不代表论文的发表时间）