Recent Advances on the Biologically Active Triterpenoids of Ganoderma lucidum
The fruit body of Ganoderma lucidum has been used as a folk medicine for various diseases as described 2000 years ago in Shen Nongs Materia Medica. The traditional medicinal efficacies of the mushroom are treatments of hepatopathy, nephritis, hypertension, hyperlipemia, arthritis, neurasthenia, insomnia, bronchitis, asthma, gastric ulcer, arteriosclerosis and diabetes. Some of these efficacies, such as cytotoxicity on hepatoma cell, inhibition of platelet aggregation, antihypertension, hypocholesterolemic activity, inhibition of histamine release, and anti- HIV activity were scientifically proved to be true by virtue of isolation of the corresponding components. Although various components such as polysaccharides, proteins, minerals and sterols have been reported from this mushroom, triterpenoids are mainly responsible for the biological activities. As more than 150 triterpenoids were reported in this medicinal fungus during the last three decades, there is a need to review most of the structures reported and their medicinal activities. The lanostane-type triterpenoids were divided into 10 groups according to their structural similarities and the known biological and medicinal activities were described in this article.
anti-HIV antihypertension bitterness cytotoxicity Ganoderma lucidum hypocholesterolemic triterpenoids
Ha Won Kim Byong Kak Kim
Department of Life Science, University of Seoul, Seoul, Korea College of Pharmacy, Seoul National University, Seoul, Korea
国际会议
2002国际灵芝专题研讨会(International Symposium on Ganoderma Research)
北京
英文
10-19
2002-10-21（万方平台首次上网日期，不代表论文的发表时间）