Protection Against Alloxan-induced Diabetes by Ganoderma lucidum Polysaccharides in Mice
This study was undertaken to investigate the protective effect against alloxan-induced diabetes in mice by Ganoderma lucidum polysaccharides (GL-PS) isolated from the fruiting body of Ganoderma lucidum (Leyss. Ex Fr.) Karst. GL-PS dose-dependently increased serum insulin contents and reduced serum glucose levels when given intragastically for continuous 10 days in alloxan-induced diabetic mice. It was found that the liver and pancreas homogenates had higher lipid peroxidation products in alloxan administered mice than in the GL-PS-treated animals. GL-PS also increase the activities of liver and pancreas catalase and pancreas GSH-px significantly in alloxan-induced diabetic mice. In addition, aldehyde fuchsin staining revealed that alloxan caused nearly all the β cells to disappear from in the pancreatic islets, while GL-PS could partly protect the β cells from necrosis. The effect of GL-PS was maximum at 200mg/kg. These results indicate that GL-PS is able to lessen the biochemical damage induced by alloxan in mice and this might be due, in part, to its antioxidant action.
Ganoderma lucidum polysaccharides hypoglycemic effect alloxan
Hui-Na Zhang Jing-Hua He Zhi-Bin Lin
Department of Pharmacology, Basic Medical School, Peking University, Health Science Center, Beijing Department of Pharmacology, Basic Medical School, Peking University, Health Science Center, Beijing,
国际会议
2002国际灵芝专题研讨会(International Symposium on Ganoderma Research)
北京
英文
165-171
2002-10-21（万方平台首次上网日期，不代表论文的发表时间）