Mycelia Powder of Ganoderma capuse, a Good Resource of Functional Food: Ⅱ. Appraisal of Safety Toxicology, Evaluation of Functional Activity
The appraised results of safety toxicology showed that the mycelia powder was safe for taking orally, nonpoisonous in reality: without any harmful effects and free from side effects to the growth of SD rats and any effects of pathological changes and causing mutation, and the lethal dosage (LD50) in Kunming mice was more than 20g/kg by orally. It also showed that the weight of tumor S-180 and tumor H-22 were lower than normal control obviously, when Kunming mice were given orally with mycelia powder in different dose (3g/kg, 1g/kg, 0.33g/kg of body weight), and this effect raising in a dose- dependent manner. Among them, it displayed a suppressive rate of 34.8％～39.7％ for tumor S-180 and 32.5％～37.7％ for tumor H-22 by taking HD (3g/kg weight). Moreover, both murine (BALB/C mice) peritoneal macrophage phagocytosis and (BALB/C mice) spleen natural-killer-cells activity were higher than normal control obviously (P<0.01, P<0.05). From the above results, it was considered that the mycelia powder were safe and nonpoisonous and free from side-effect for taking orally, while it were displayed tumor suppressive activity and immunomodulating activity. It was considered that the mycelia powder was accorded completely with the demands of health protection food (functional food).
Ganoderma capuse mycelia powder safety toxicology functional activity
Kai-Ben Li Ti-Qiang Chen Zhong-Wang Fan Pei-Gen Zhu
Medicinal fungus Research & Development Center of Fujian Academy of Agricultural Sciences, Fuzhou, F Institute of Fuzhou Minjiang Fungus Bioengineering, Fuzhou, Fujian Province, China
国际会议
2002国际灵芝专题研讨会(International Symposium on Ganoderma Research)
北京
英文
209
2002-10-21（万方平台首次上网日期，不代表论文的发表时间）