Poly(N-isopropylacrylamide)-based Smart Membranes for Chiral Separation
A novel thermo-responsive smart membrane for chiral separation with a high performance has been developed. The membrane exhibited chiral selectivity based on molecular recognition of beta-cyclodextrin (β -CD) and thermo-sensitivity based on phase transition of poly(N-isopropylacrylamide) (PNIPAM). Linear PNIPAM chains were grafted onto porous Nylon-6 membrane substrates by using plasma-graft pore-filling polymerization method, acting as micro-environmental adjustors for β -CD molecules. β -CD moieties were introduced into the linear PNIPAM chains by chemical grafting polymerization method, acting as chiral selectors. The phase transition of grafted PNIPAM chains affected the micro-environment of β -CD molecules and then the association between β -CD and guest molecules. The chiral selectivity of the prepared thermo-responsive membranes in chiral separation operated at temperature below the lower critical solution temperature (LCST) of PNIPAM was higher than that of membranes with no thermo-sensitivity. Furthermore the decomplexation ratio of enantiomer-loaded thermo-responsive membranes in decomplexation operated at temperature above the LCST was much higher than that of membranes with no thermo-sensitivity. Thus, by simply changing the operation temperature, high selective chiral separation and efficient membrane regeneration were achieved. The proposed membrane provided a new efficient way to solve the difficult decomplexation problem of chiral solid membranes, which is highly attractive in chiral separation.
membranes enantioseparation chiral separation thermo-responsive polymer
Mei Yang Liang-Yin Chu Hai-Dong Wang Rui Xie Hang Song Catherine Hui Niu
School of Chemical Engineering, Sichuan University, Chengdu, Sichuan, 610065, China; 2 Department of Chemical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK S7N 5
国际会议
The 5th International Conference on Separation Science and Technology(第五届国际分离科学与技术会议)
北京
英文
2007-10-14(万方平台首次上网日期,不代表论文的发表时间)