Recrystallization of Oral Drug in Supercritical Carbon Dioxide
Drug fine particle was prepared by using an Aerosol Solvent Extraction System (ASES) with supercritical CO2. The effect of the weight ratio of CO2 to solution, solvent type, and solution concentration on the particle size and morphology was investigated. The particle morphology was analyzed by a Scanning Electron Microscopy (SEM). The size of primary particle was measured to be 0.1~0.2 |ì m and the shape was similar to spherical type. The size of secondary particle was about 0.3~0.6 |ì m, as a result of primary particle agglomeration, the shape was irregular. After ASES process the CPD particle was remained as amorphous form.
Aerosol solvent extract system Supercritical fluid Particle formation Drug
Junho Chu Guanghua Li Kyung Ho Row Hwayong Kim Youn-Woo Lee
School of Chemical & Biological Engineering and Institute of Chemical Process, Seoul National Univer Center for Advanced Bioseparation Technology, Department of Chemical Engineering, Inha University,25
国际会议
The 5th International Conference on Separation Science and Technology(第五届国际分离科学与技术会议)
北京
英文
2007-10-14（万方平台首次上网日期，不代表论文的发表时间）