Developments of Si Based Planer Type Ion-Channel Biosensor
The planer type patch clamp biosensor is developed using Si on insulator (SOI) substrates. The micro-pore structure is designed considering the optimization to reduce the noise. The TRPV1 ion channel-transfected HEK293 cell is positioned on the micropore and the Si chip is integrated into the microfluidic circuit. The whole cell arrangement is formed using the ionophore. The ligand gated channel current is observed successfully using capsaicin as a ligand molecule. The future application of this device to the neural network analyzer to investigate the pathogenesis mechanisms of neuro-degenerative diseases.
patch clamp biosensor ion channel Si neurodegenerative disease neural network.
Tsuneo Urisu
Institute for Molecular Science/Graduate University for Advanced Studies,Myodaiji,Okazaki,444-8585 Japan
国际会议
The 5th International Forum on Post-genome Technologies(5IFPT)(第五届国际后基因组生命科学技术学术论坛)
苏州
英文
2007-09-10（万方平台首次上网日期，不代表论文的发表时间）