Analysis of GABRB1 association with Autism in Chinese Han Population with SNP genotyping

摘要：

Autism is a complex neurodevelopment disorder with a broad spectrum of symptoms and varying severity. The gamma-aminobutyric acid (GABA) A receptor (GABRB1) is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. We examined the association of GABRB1 genes with autism, in a SNP genotyping analysis, using DNA samples from trio families recruited which included 117 Chinese Han family trios with autism and 120 normal individuals. We selected rs2351299 and rs3832300 as candidate SNP sites, and found that rs2351299 is associated with Autistic patients who have linguistic problem (chi-square 4.088194, p=0.043237)，while rs3832300 is not significantly associated in our sample with autism.

关键词： SNP GABRB1 Autism

作者: Yuanzhuo Zheng Yu Sun Wenjing Chen Beili Sun Lu Cheng Xiaoyan Ke Zuhong Lu

作者单位: State Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096, China Research Center for Learning Science, Southeast University, Nanjing, 210096, China

会议类型: 国际会议

会议名称: The 5th International Forum on Post-genome Technologies(5IFPT)(第五届国际后基因组生命科学技术学术论坛)

会议地点: 苏州

会议语种:英文

在线出版日期: 2007-09-10（万方平台首次上网日期，不代表论文的发表时间）