NMR-based Metabonomic Studies on the Renal and Hepatic Toxicity of Traditional Chinese Medicine

摘要：

A metabonomic approach based on 1H-NMR spectroscopy, pattern recognition and principle component analysis have been applied for the prediction and evaluation of renal and hepatic toxicity of traditional Chinese medicine. NMR spectra of the endogenetic metabolites from rat urines treated with pyrrolizidine alkaloids (PAs) and cimicidol-3-O-β-D-xyloside (CX), an active component isolated from Cimicifugae rhizoma were measured and statistically analyzed. Toxin-induced changes of endogenetic metabolites could be clearly reflected via the NMR spectra coupled with PCA results. The studies have shown that the renal and hepatic toxicity of the samples could be analyzed simply and rapidly using the metabonomic method.

关键词： Metabonomics NMR pyrrolizidine alkaloids cimicidol-3-O-β-D-xyloside TCM toxicity principal component analysis

作者: Cui-Cui He Jia Hua Jian-Xin Li

作者单位: Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China, 210093

会议类型: 国际会议

会议名称: The 5th International Forum on Post-genome Technologies(5IFPT)(第五届国际后基因组生命科学技术学术论坛)

会议地点: 苏州

会议语种:英文

在线出版日期: 2007-09-10（万方平台首次上网日期，不代表论文的发表时间）