Spectroscopic Studies on the Interaction of an Organoruthenium Carborane Complex with Hemoglobin
In this work, the interaction between a new organoruthenium complex bearing one carboranyl and one ferrocenyl groups (denoted as 1) and hemoglobin (Hb) has been investigated under physiological pH 7.2 by using fluorescence and UV-Vis absorption spectroscopy as well as synchronous fluorescence spectroscopy. The combined results of fluorescence and synchronous fluorescence spectroscopy illustrate that although 1 has neglectable influence on the Soret-band and Q-band of Hb, yet 1 could mainly interact with Hb at tryptophan residues and lead to the fluorescence quenching of Hb during the process of interaction. These observations suggest the possibility for the design and synthesis of new organometallic carborane derivatives as potent BNCT (boron neutron capture therapy) agents or anticancer drugs in biomedical areas.
Organoruthenium carborane complex Hemoglobin Protein interaction Spectroscopic study
Chunhui Wu Dehong Wu Dadong Guo Hong Yan Xuemei Wang
State Key Lab of Bioelectronics (Chien-Shiung Wu Lab), Southeast University, Nanjing, Jiangsu 210096 State Key Lab of Coordination Chemistry, School of Chemistry and Chemical Engineering, The Joint Lab
国际会议
The 5th International Forum on Post-genome Technologies(5IFPT)(第五届国际后基因组生命科学技术学术论坛)
苏州
英文
2007-09-10（万方平台首次上网日期，不代表论文的发表时间）