A family-based and case-control association study of GABRB3 gene in Chinese Autistics

摘要：

Autism is a complex genetic neurodevelopment disorder. Chromsome 15 is a candidate region for autism susceptibility. Single nucleotide polymorphisms (SNPs) of Gamma-aminobutyric acid A receptor, beta 3 (GABRB3), were previously considered to be associated with autism in the Caucasian population. Two SNPs of GABRB3 were selected for genotyping with 130 autistic families and 120 healthy controls, using family and case-control analysis, based on poly-acrylamide gel DNA microarray. Our current results showed no significant association between GABRB3 gene and Chinese autistics (p>0.05).

关键词： GABRB3 SNP autism TDT case-control

作者: Bei-Li Sun Lu Cheng Xiao-Yan Ke Ying Zhou Ping Chen Yu Sun Yuan-Zhuo Zheng Ming-Hao Zhang Zu-Hong Lu

作者单位: State Key Laboratory of Bioelectronics, Southeast University Key Laboratory of Child Development and Learning Science, Ministry of Education, Research Center for Key Laboratory of Child Development and Learning Science, Ministry of Education, Research Center for State Key Laboratory of Bioelectronics, Southeast University; Key Laboratory of Child Development an

会议类型: 国际会议

会议名称: The 5th International Forum on Post-genome Technologies(5IFPT)(第五届国际后基因组生命科学技术学术论坛)

会议地点: 苏州

会议语种:英文

在线出版日期: 2007-09-10（万方平台首次上网日期，不代表论文的发表时间）