17b-estradiol and CpG-ODN Synergetically Activate Plasmacytoid Dendritic cells

摘要：

Physiological gender differences in immune capabilities suggest that sex steroid hormones such as 17b-estradiol (E2) may be involved in the regulation of the immunocompetence. In this paper, plasmacytoid dendritic cells (pDC) from murine spleen were treated with E2 or/and CpG-ODN (CpG) for 24h or 72h. Then the viability, costimulatory molecules expression, cytokines secretion and stimulatory capacity were analyzed. Our results showed that E2 and CpG increased the viability of pDCs, and upregulated the expression of CD80, CD86 and CD40 on pDCs. Both E2 and CpG also increased IFN-a secretion and the stimulatory capacity of pDCs. These data suggested that E2 and CpG might synergetically influence the immune responses by changing the viability, maturation, stimulatory capacity and cytokine secretion of pDCs.

关键词： plasmacytoid dendritic cell 17b-Estradiol CpG-ODN

作者: Xiao-Xi Li Yi-Xin Xu Ling Ma Ya-Yi Hou

作者单位: Immunology and Reproductive Biology Lab, Nanjing University, Nanjing 210093, PR China

会议类型: 国际会议

会议名称: The 5th International Forum on Post-genome Technologies(5IFPT)(第五届国际后基因组生命科学技术学术论坛)

会议地点: 苏州

会议语种:英文

在线出版日期: 2007-09-10（万方平台首次上网日期，不代表论文的发表时间）