Effects of glucocorticoids on expression of CD4+ Foxp3+ T cell in patients with systemic lupus erythematosus
The Purpose of this study was to investigate whether the number of CD4+ Foxp3+ T cells was abnormal in patients with systemic lupus erythematosus (SLE) and observe the effect of glucocorticoids on CD4+ Foxp3+ in patients with SLE. The percentage of CD4+ Foxp3+ T cells in peripheral blood was detected by flow cytometry in 26 SLE patients and 5 healthy controls. Linear regression was used to analyze correlation between the percentage of CD4+ Foxp3+ T cells and lupus activity. The percentage of CD4+ Foxp3+ T cells in active SLE patients was lower than that in both inactive SLE and normal controls, but without significant difference. The percentage of CD4+ Foxp3+ T cells in SLE patients treated with steroids was increased compared with without treatment (P<0.05). There was no significant correlation between the percentage of CD4+ Foxp3+ T cells and SLE disease activity index. However, the percentage of CD4+ Foxp3+ T cells was positively correlated with the dosage of glucocorticoids per day (P<0.05).
T-lymphocytes regulatory Foxp3 Glucocorticoids Lupus erythematosus systemic
Sheng-nan Zhao Ya-yi Hou Ling-yun Sun
The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China Immunology Lab, Nanjing University Medical SchoolChina The Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu 210008, China
国际会议
The 5th International Forum on Post-genome Technologies(5IFPT)(第五届国际后基因组生命科学技术学术论坛)
苏州
英文
2007-09-10（万方平台首次上网日期，不代表论文的发表时间）