Lack of Association Between SLC25A12 and Autism in Chinese Han Population

摘要：

Autism is a complex, largely genetic neurodevelopmental disorder. Earlier studies have defined several susceptibility chromosomal regions. SLC25A12 located in 2q24-q33, one of the susceptibility regions, and significant association with autism has been reported for two SNPs (rs2056202, rs2292813) in SLC25A12. We attempt to replicate the results in Chinese Han people using the case–control comparison, transmission disequilibrium test and haplotype analysis. Our studies failed to find any significant association for SNPs test, suggesting that SLC25A12 is not a major contributor to autism susceptibility in Chinese Han people.

关键词： autism SNP association SLC25A12

作者: Ying Zhou Yu Sun Minghao Zhang Min-jie Wang Zu-hong Lu Xiao-yan Ke Lu Cheng Pengfeng Xiao Bing Zou Yue-yue Hang Bei-li Sun Ping Chen Yuanzhuo Zheng

作者单位: 1. Key Laboratory of Child Development and Learning Science, Ministry of Education, Research Center State Key Laboratory of Bioelectronics, Southeast University, Nanjing, China, 210096 Key Laboratory of Child Development and Learning Science, Ministry of Education, Research Center for Key Laboratory of Child Development and Learning Science, Ministry of Education,Research Center for Key Laboratory of Child Development and Learning Science, Ministry of Education, Research Center for Child Mental Health Research Center of Nanjing Brain Hospital affiliated of Nanjing Medical Universi

会议类型: 国际会议

会议名称: The 5th International Forum on Post-genome Technologies(5IFPT)(第五届国际后基因组生命科学技术学术论坛)

会议地点: 苏州

会议语种:英文

在线出版日期: 2007-09-10（万方平台首次上网日期，不代表论文的发表时间）