Study on Association between Autism and Genotypes of Tryptophan 2, 3 Dioxygenase in Chinese Han Population

摘要：

Serotonin is an important neurotransmitter in autism. Tryptophan 2,3 dioxygenase (TDO2) as the rate-limiting enzyme in the catabolism of tryptophan, the precursor of serotonin, its gene mutation can decrease activity of enzyme, then increase the level of whole body serotonin. We have investigated four single nucleotide polymorphisms in the TDO2 gene for association with autistic disorder. One hundred and twelve Chinese autistic disorder families were tested using transmission disequilibrium test. There was a significant difference in the transmission of a promoter variant to autistic patients (P=0.009). Haplotype analysis also demonstrated significant difference in the transmission of TDO2 haplotypes to autistic subjects. Our results provide further support of a genetic association between TDO2 and autism.

关键词： autism TDO2 serotonin Single nucleotide polymorphism linkage disequilibrium haplotype

作者: Xiaoyan Ke Yuanzuo Zheng Minjie Wang Zuhong Lu Lu Cheng Bing Zou Ying Zhou Ping Chen Beili Sun Yueyue Hang Minghao Zhang Yu Sun

作者单位: 1 Research Center for Learning Science of Southeast University Nanjing, China 210096; Child Mental H State Key Laboratory of Bioelectronics, Southeast University Child Mental Health Research Center of Nanjing Brain Hospital affiliated of Nanjing Medical Universi Research Center for Learning Science of Southeast University, Nanjing, China 210096; State Key Labor Research Center for Learning Science of Southeast University, Nanjing, China 210096

会议类型: 国际会议

会议名称: The 5th International Forum on Post-genome Technologies(5IFPT)(第五届国际后基因组生命科学技术学术论坛)

会议地点: 苏州

会议语种:英文

在线出版日期: 2007-09-10（万方平台首次上网日期，不代表论文的发表时间）